Epitalon

DNot approvedMitochondrial, antioxidant and longevity compounds →EpithalonEpithaloneAEDG peptide
In one paragraphEpitalon is a synthetic four-amino-acid peptide (Ala-Glu-Asp-Gly) developed in St Petersburg in the 1980s and promoted for longevity on the basis of telomerase activation in cell culture and lifespan effects in mice. The human evidence comes from one research group, is uncontrolled, and much of it used Epithalamin — a pineal-gland extract — rather than the synthetic peptide sold under the name. It is not approved anywhere.
Schematic 3D structure of Epitalon
4 residues · tetrapeptide Ala-Glu-Asp-Gly · schematic
Overall gradeD No human evidence
Human trialsUncontrolled, single group
Outcomes graded4
Last reviewed2 September 2026
EvidenceWhat it isHow it worksUnknownsMolecule & PKRegulationQuestionsReferences

What the human research shows

The clearest case on this site of evidence being borrowed across products. The long-term human observations that get cited for epitalon were mostly done with Epithalamin, a bovine pineal extract from the same institute. The synthetic tetrapeptide has cell and mouse data behind it, and one uncontrolled human series.

MetabolicCardioMuscleHealingNeuroImmuneSexualSkinAgeing

Evidence profile0–5

  • Metabolic & weight—0.0
  • Cardiovascular—0.0
  • Muscle & growth—0.0
  • Healing & repair—0.0
  • Neuro & sleepD0.0
  • Immune & inflammation—0.0
  • Sexual & hormonal—0.0
  • Skin & appearance—0.0
  • Ageing & longevityD0.0
No benefit outcome for Epitalon has both human evidence and a measurable effect, so the profile is empty. That is the finding, not a gap in the chart.
OutcomeGradeEffect sizeHuman studiesWhere the evidence comes from
Lifespan / mortalityDNo human evidenceNot measurableUncontrolled, single groupA 12–15-year observational follow-up of elderly patients from one institute reported lower mortality with Epithalamin (the extract) plus thymus extract. No randomisation, no blinding, and not the synthetic peptide.1
Telomerase activationDNo human evidenceNot measurableCell culture onlyTelomerase activity and telomere lengthening reported in cultured human fibroblasts. Never measured in a living person.2
Melatonin / sleepDNo human evidenceNot measurableSmall uncontrolledSmall studies from the same group report restored night-time melatonin in elderly subjects; uncontrolled and unreplicated.3
Safety in humansadverseDNo human evidenceNot measurableNone systematicNo adverse-event data collected to modern standards. Unknown is not the same as safe.
AMultiple good human trials, consistentBSome human trials, mostly consistentCFew or weak human studiesDAnimal or anecdotal onlyeffect size · red = adverse

Literature searched to 2 September 2026. Human studies only; animal and cell work informs the mechanism section and nothing else.

What it is

Epitalon is a synthetic peptide designed by Vladimir Khavinson's group at the St Petersburg Institute of Bioregulation and Gerontology to mimic Epithalamin, an extract of cattle pineal glands the same institute had studied since the 1970s. The synthetic version is four amino acids long and is the product sold on the grey market today.

Almost the entire literature — cell, animal and human — comes from that institute and its collaborators, was published largely in Russian-language journals, and has not been independently replicated. That does not make it wrong; it makes it unverified.

How it is thought to work

The proposed mechanism is activation of telomerase, the enzyme that maintains the ends of chromosomes, plus regulation of the pineal gland's melatonin output. Both have support in cell culture and in rodents from the originating group. Neither has been demonstrated in humans.

What is still unknown

  • Whether the synthetic peptide does what the pineal extract was reported to do; they are different products.
  • Whether any of the cell-culture telomerase findings occur in a living person.
  • Whether activating telomerase, if it happened, would be desirable — the same enzyme is switched on in most cancers.

The molecule and how long it lasts

Identity
Formula
C14H22N4O9
Molecular weight
390.35 g/mol
CAS number
307297-39-8
PubChem
CID 219042

PubChem record, read 23 September 2026.

Pharmacokinetics
Route
Injected or intranasal as sold; no human PK study
Half-life
No human pharmacokinetic data

No pharmacokinetic study in people.

Regulatory status

European Union
Unauthorised medicinal product

No marketing authorisation in any member state. Supplying it for human use is an offence under national medicines law; 'research use only' labels do not change that. Epithalamin products are authorised in Russia only.

United States
Not approved; compounding under review

Removed from FDA's Category 2 list on 22 April 2026; the Pharmacy Compounding Advisory Committee recommended it for the 503A bulks list in July 2026 (recommended 24 July 2026). Not on the list yet and not an approved drug. Sold otherwise as an unapproved 'research chemical'.

United Kingdom
Unlicensed medicine

Not licensed by the MHRA. Selling or supplying it is an offence under the Human Medicines Regulations 2012; importing a small quantity purely for personal use is not itself an offence, but consignments are seized.

Australia
Schedule 4, unapproved

Prescription-only substance not on the ARTG. Possession without a prescription is an offence; imports without a prescription are seized.

Canada
Not authorised

No Drug Identification Number; selling it is illegal. Residents cannot import prescription drugs by mail.

Sport (WADA)
Prohibited at all times

Not named, but unapproved anywhere, so it falls under S0 (non-approved substances).

Questions people actually ask

Does epitalon extend lifespan?
In mice, some studies from one group report modest lifespan effects. In humans there is no controlled evidence. The often-cited 12–15-year follow-up used Epithalamin, a pineal extract, not the synthetic peptide, and had no control group.
Does epitalon lengthen telomeres?
In cultured cells, one group has reported telomerase activation. It has never been measured in people taking the peptide.
Is epitalon safe?
Unknown. No systematic safety data exist. If it did activate telomerase in vivo, that would be a reason for caution, not reassurance.

One page per claimed effect

References

  1. 1
    Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life.Neuro Endocrinol Lett, 2003;24:233–240Uncontrolled long-term observation with Epithalamin (extract) and Thymalin.
  2. 2
    Khavinson VKh, et al. Peptide promotes overcoming of the division limit in human somatic cell.Bull Exp Biol Med, 2003;135:503–506Cell-culture telomerase and telomere findings.
  3. 3
    Korkushko OV, et al. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging.Bull Exp Biol Med, 2006;142:356–359Uncontrolled; Epithalamin extract, not the synthetic peptide.

Change log

  • 2026-09-02Full page. Separated evidence for the synthetic peptide from evidence for the Epithalamin extract; added telomerase, melatonin and safety rows.
  • 2026-09-01Initial publication.