Editorial policy

Who writes LYO, and how it is checked

In one paragraphLYO Research is written and maintained under organisational authorship: the organisation, not an individual, is accountable for every page. Every factual claim is traced to a named primary source — a trial, a regulator document, a published paper — so that a page is checkable rather than something you have to take on trust. This page sets out exactly how a page is built, what LYO does not yet have, and how to get something corrected.

Authorship

Pages on LYO carry no personal byline. They are published by LYO Research as an organisation, in the way that Cochrane reviews, IARC monographs and most scientific reference databases are published: the institution takes responsibility, and the argument stands on its sources rather than on the reputation of whoever typed it.

That is a deliberate choice, and it comes with an obligation. Because there is no personal authority behind a claim, every claim has to carry its own evidence. That is why each outcome row names the trials behind it, with participant numbers and results, and why the underlying sentence from the paper is quoted directly rather than summarised. If a page is wrong, it is LYO's error, and LYO corrects it publicly with a date.

How a page is built

  1. Literature search. PubMed, ClinicalTrials.gov and the relevant regulators are searched for human studies of the compound. The date that search was last run is printed on the page — “literature searched to” — so you can see how current it is.
  2. Human evidence only. Grades are assigned on controlled human evidence. Animal and cell work informs the mechanism section and never lifts a grade above D. See the grading methodology.
  3. Primary sources, numbered. Every outcome row links to the specific trials behind it. Where a DOI or PMID is verified it is used; where it is not, a search link is given rather than a guessed identifier.
  4. Verbatim quotation. Where a trial result is quoted, the sentence is copied exactly as printed in the source abstract, checked character by character against the original, and shown in a cited block. Quotes are never paraphrased, never trimmed mid-sentence, and never reconstructed from memory. If a sentence cannot be reproduced exactly, no quote is shown.
  5. Regulatory status per jurisdiction. Approval status is checked separately for each jurisdiction LYO covers against that regulator's own documents, and dated.
  6. Press releases are flagged. Where a result rests on a company announcement rather than a peer-reviewed paper, the page says so and the grade is capped accordingly.
  7. Dated change log. Every page carries its own revision history, so you can see what changed and when.

What LYO does not have

This section exists because a reference that only lists its strengths is not being straight with you.

LYO has no external scientific reviewer at this time. No page on this site claims to be peer-reviewed, expert-reviewed, or endorsed by a clinician or researcher, because none is. Wording like “medically reviewed” appears nowhere on LYO, and will not appear unless and until a named, credentialed reviewer is actually doing that work.

What LYO offers in place of that is traceability. You are not asked to believe a grade because an expert signed it; you are given the trials, the numbers and the exact sentence from the paper, so you can check the grade yourself and disagree with it if the evidence says otherwise. That is a weaker claim than expert review, and an easier one to verify.

If a qualified reviewer joins the project, they will be named here with their credentials and institutional affiliation, and the specific pages they reviewed will say so with a date. Nothing will be described as reviewed in the abstract.

Corrections

Corrections are made publicly and dated in the page's change log. Nothing is quietly edited. If a grade changes because the evidence changed, the log says what changed and why.

If you find an error — a misread result, a superseded trial, a regulatory status that has moved, a quote that does not match its source — send it here. A page, a row and the study that contradicts it is the fastest possible correction. Corrections are welcome from anyone; no credentials required, only a source.

Funding and conflicts of interest

LYO Research has no revenue. It sells nothing, hosts no advertising, runs no affiliate links, and takes no sponsorship. It has no commercial relationship with any manufacturer, supplier, compounding pharmacy or clinic, and it does not link to vendors or list prices anywhere on the site.

Should any of that change, it will be disclosed on this page and on every page it touches, before it takes effect.

Reuse and citation

The full dataset behind the site is published under CC BY 4.0 and available as structured JSON, so that anyone — including researchers and other publications — can check the underlying records or reuse them with attribution. That is the strongest form of accountability a reference can offer: the data is open to inspection, not just the conclusions.

Scope and limits of use

LYO is a research and educational reference. It is not medical advice, not a recommendation, and not an instruction for use. Grades describe the state of the human evidence — not safety, not legality, and not whether a compound is appropriate for any individual. Those questions belong with a clinician.

Editorial policy last updated 7 October 2026.