Definition
A compound that stimulates the pituitary to release growth hormone. GHRH analogues (sermorelin, CJC-1295, tesamorelin) act on the GHRH receptor; ghrelin mimetics (ipamorelin, GHRP-2, GHRP-6, ibutamoren) act on the ghrelin receptor. Raising growth hormone in a blood test is easy to show; showing that it changes body composition or health in adults is not, and for most of these it has never been done.
Where it matters on LYO
- CIpamorelin1 RCT (negative) + small early-phase
- CSermorelinApproved paediatric use; small adult studies
- CCJC-1295Early-phase only; programme discontinued
- BTesamorelinSeveral RCTs
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