Definition
Glucose-dependent insulinotropic polypeptide, the other incretin hormone. On its own it does little for weight; combined with GLP-1 activity in a single molecule, as in tirzepatide, it appears to add several percentage points of weight loss and better tolerability.
Where it matters on LYO
- ATirzepatide15+ RCTs
- BRetatrutide3 phase 3 RCTs published (n=2,339; n=1,152; n=537); 2 phase 3 topline
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