Does Pinealon help with hypoxia tolerance? Grade D evidence

What the studies show

Aged rats given pinealon before hypoxia showed behavioural and caspase-3 changes in several small studies from the same institute.

Animal studies, cell studies, or anecdotes only. This is where almost every viral peptide sits. Promising and proven are different words for a reason.

1
PubMed search: pinealon — 22 results; human reports Russian-language without indexed abstracts (Meshchaninov 2015; Nazimko 2012).PubMed, searched 2026-09-23

In context

Pinealon is the tripeptide Glu-Asp-Arg, a synthetic 'bioregulator' from the St Petersburg group behind epitalon, sold for brain ageing and stress. Its indexed evidence is cell culture — it reduced free radicals and cell death in vitro — and rat experiments in hypoxia. The human reports are Russian-language, without controls and without indexed abstracts. No randomised trial exists. It is not approved anywhere this site covers.

Pinealon is not approved. Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is Pinealon proven to help with hypoxia tolerance?

No. There is no human evidence for it (Animal only); the claim rests on animal or cell studies and LYO grades it D.

What studies are behind the grade?

Aged rats given pinealon before hypoxia showed behavioural and caspase-3 changes in several small studies from the same institute.

Is Pinealon approved for this?

No. Pinealon is not approved; it is not an approved medicine for any indication in the jurisdictions LYO covers.

Other outcomes for Pinealon

DCognition or brain ageing (human)0 controlled; Russian reports without abstracts
DCell viability under oxidative stress (in vitro)Cell culture only

Written and maintained by LYO Research — how pages are written and checked. Reviewed 23 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →