Does Pinealon help with cell viability under oxidative stress? Grade D evidence

What the studies show

Khavinson's 2011 study reports lower free-radical levels and less necrotic death in cultured cells — the origin of the neuroprotection claim.

Animal studies, cell studies, or anecdotes only. This is where almost every viral peptide sits. Promising and proven are different words for a reason.

1
Khavinson V, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.Rejuvenation Res, 2011Cell culture.

In context

Pinealon is the tripeptide Glu-Asp-Arg, a synthetic 'bioregulator' from the St Petersburg group behind epitalon, sold for brain ageing and stress. Its indexed evidence is cell culture — it reduced free radicals and cell death in vitro — and rat experiments in hypoxia. The human reports are Russian-language, without controls and without indexed abstracts. No randomised trial exists. It is not approved anywhere this site covers.

Pinealon is not approved. Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is Pinealon proven to help with cell viability under oxidative stress?

No. There is no human evidence for it (Cell culture only); the claim rests on animal or cell studies and LYO grades it D.

What studies are behind the grade?

Khavinson's 2011 study reports lower free-radical levels and less necrotic death in cultured cells — the origin of the neuroprotection claim.

Is Pinealon approved for this?

No. Pinealon is not approved; it is not an approved medicine for any indication in the jurisdictions LYO covers.

Other outcomes for Pinealon

DCognition or brain ageing (human)0 controlled; Russian reports without abstracts
DHypoxia tolerance (rats)Animal only

Written and maintained by LYO Research — how pages are written and checked. Reviewed 23 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →