Does Pinealon help with cognition or brain ageing? Grade D evidence

What the studies show

Two Russian-language clinical reports (2012, 2015) are indexed by title only and describe uncontrolled use. LYO could not read a method or a result.

Animal studies, cell studies, or anecdotes only. This is where almost every viral peptide sits. Promising and proven are different words for a reason.

1
PubMed search: pinealon — 22 results; human reports Russian-language without indexed abstracts (Meshchaninov 2015; Nazimko 2012).PubMed, searched 2026-09-23

In context

Pinealon is the tripeptide Glu-Asp-Arg, a synthetic 'bioregulator' from the St Petersburg group behind epitalon, sold for brain ageing and stress. Its indexed evidence is cell culture — it reduced free radicals and cell death in vitro — and rat experiments in hypoxia. The human reports are Russian-language, without controls and without indexed abstracts. No randomised trial exists. It is not approved anywhere this site covers.

Pinealon is not approved. Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is Pinealon proven to help with cognition or brain ageing?

No. There is no human evidence for it (0 controlled; Russian reports without abstracts); the claim rests on animal or cell studies and LYO grades it D.

What studies are behind the grade?

Two Russian-language clinical reports (2012, 2015) are indexed by title only and describe uncontrolled use. LYO could not read a method or a result.

Is Pinealon approved for this?

No. Pinealon is not approved; it is not an approved medicine for any indication in the jurisdictions LYO covers.

Other outcomes for Pinealon

DCell viability under oxidative stress (in vitro)Cell culture only
DHypoxia tolerance (rats)Animal only

Written and maintained by LYO Research — how pages are written and checked. Reviewed 23 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →