Definition
The fraction of a dose that reaches the circulation intact. Swallowed peptides are mostly digested, so oral bioavailability is close to zero for nearly all of them; oral semaglutide manages around 1% with an absorption enhancer. Claims for peptide capsules, sprays and creams stand or fall on this number.
Where it matters on LYO
- ASemaglutide30+ RCTs
- DBPC-1570 controlled
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