Adverse effect · Lixisenatide

How common is GI side effects with Lixisenatide?

A
Grade A — established in humansAll trials · effect size: moderate · adverse
Short answerEstablished in humans. All trials point the same way: a moderate effect. The class profile; in the Parkinson's trial, where participants were not diabetic, nausea affected almost half.

What the studies show

The class profile; in the Parkinson's trial, where participants were not diabetic, nausea affected almost half.

“Nausea occurred in 46% of participants receiving lixisenatide, and vomiting occurred in 13%.”

Verbatim, from the abstractMeissner WG, et al. Trial of lixisenatide in early Parkinson's disease (LIXIPARK). N Engl J Med, 2024;390:1176–1185

Several well-run randomised trials in people, pointing the same way. You can plan around this. It still says nothing about whether the effect is worth the side effects for you.

  1. 1
    Meissner WG, et al. Trial of lixisenatide in early Parkinson's disease (LIXIPARK).N Engl J Med, 2024;390:1176–1185156 randomised, 12 months. NCT03439943.

In context

Lixisenatide is a short-acting GLP-1 receptor agonist derived from exendin-4, approved for type 2 diabetes since 2013 and now sold mainly in combination with insulin glargine. Its cardiovascular-outcomes trial in 6,068 people after a heart attack was neutral. In 2024 a French phase 2 trial found that a year of lixisenatide slowed motor progression in early Parkinson's disease by about three points on the standard scale, with nausea in nearly half. It is prescription-only; the standalone product has been withdrawn in some markets.

Lixisenatide is approved (rx). Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is Lixisenatide proven to cause GI side effects?
Yes, as far as human trials can show it: All trials. LYO grades this outcome A.
What studies are behind the grade?
The class profile; in the Parkinson's trial, where participants were not diabetic, nausea affected almost half.
Is Lixisenatide approved for this?
Lixisenatide is an approved medicine (Approved (Rx)); whether this particular outcome is a licensed indication is stated on the compound page's regulation section.

Other outcomes for Lixisenatide

Written and maintained by LYO Research — how pages are written and checked. Reviewed 23 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →