What the studies show
A single injection reliably provokes an LH and FSH response, which is the basis of its licence as a pituitary-function test. Not in dispute.
Several well-run randomised trials in people, pointing the same way. You can plan around this. It still says nothing about whether the effect is worth the side effects for you.
- 1Gonadorelin 100 micrograms powder for solution for injection — Summary of Product Characteristics.MHRA / emc, UKLicensed diagnostic use.
In context
Gonadorelin is synthetic gonadotropin-releasing hormone, the ten-amino-acid signal the hypothalamus sends to make the pituitary release LH and FSH. Given in pulses by pump it restores fertility in men and women whose own signal is missing; given once it is a licensed test of pituitary function. Neither is what it is mostly sold for today: clinics add it to testosterone replacement to 'keep the testes working', a use that has never been tested in a trial. It is prohibited for male athletes.
Gonadorelin (GnRH) is licensed (diagnostic / pulsatile); trt use unstudied. Legal status differs by country — see the regulation section or the jurisdiction pages.
Questions
Is Gonadorelin (GnRH) proven to help with LH and FSH release?
What studies are behind the grade?
Is Gonadorelin (GnRH) approved for this?
Other outcomes for Gonadorelin (GnRH)
- BFertility in hypogonadotropic hypogonadism (pulsatile pump)7 comparative studies, 420 men (meta-analysis); many small series
- DPreserving testicular function on testosterone therapyNone
- BAdverse effectsadversePulsatile-therapy series
Written and maintained by LYO Research — how pages are written and checked. Reviewed 10 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →