Claimed effect · DSIP (delta sleep-inducing peptide)

Does DSIP (delta sleep-inducing peptide) help with opioid withdrawal?

D
Grade D — no human evidence1 open trial · effect size: not measurable
Short answerNo human evidence. As of 3 September 2026, only 1 open trial exists for DSIP (delta sleep-inducing peptide) for opioid withdrawal. An open-label study in opioid detoxification was published in 1998. Without a control group it cannot separate the peptide from the natural course of withdrawal, and it was not followed up.

What the studies show

An open-label study in opioid detoxification was published in 1998. Without a control group it cannot separate the peptide from the natural course of withdrawal, and it was not followed up.

Animal studies, cell studies, or anecdotes only. This is where almost every viral peptide sits. Promising and proven are different words for a reason.

  1. 1

In context

DSIP is a nine-amino-acid peptide isolated from rabbit brain in the 1970s and named for the sleep pattern it appeared to induce. Unusually for a grey-market sleep peptide, it was tested in people: several small studies in chronic insomnia through the 1980s and 90s. The best-controlled of them found effects that were weak, possibly artefactual, and concluded it was unlikely to be of major therapeutic benefit. Development stopped.

DSIP (delta sleep-inducing peptide) is not approved. Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is DSIP (delta sleep-inducing peptide) proven to help with opioid withdrawal?
No. There is no human evidence for it (1 open trial); the claim rests on animal or cell studies and LYO grades it D.
What studies are behind the grade?
An open-label study in opioid detoxification was published in 1998. Without a control group it cannot separate the peptide from the natural course of withdrawal, and it was not followed up.
Is DSIP (delta sleep-inducing peptide) approved for this?
No. DSIP (delta sleep-inducing peptide) is not approved; it is not an approved medicine for any indication in the jurisdictions LYO covers.

Other outcomes for DSIP (delta sleep-inducing peptide)

Written and maintained by LYO Research — how pages are written and checked. Reviewed 3 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →