Adverse effect · Cagrilintide

How common is GI side effects with Cagrilintide?

B
Grade B — probable, not settledPhase 3 · effect size: moderate · adverse
Short answerProbable, not settled. Human data exist (Phase 3) and mostly agree, showing a moderate effect — but too few, too small, or not yet peer-reviewed for a firm answer. Mostly mild-to-moderate nausea and vomiting, easing over time; the profile reported as consistent with GLP-1 drugs.

What the studies show

Mostly mild-to-moderate nausea and vomiting, easing over time; the profile reported as consistent with GLP-1 drugs.

Human trials exist and mostly agree, but there are too few of them, they are too small, or one big one is still reading out. Expect the grade to move.

  1. 1
    Coadministered cagrilintide and semaglutide in adults with overweight or obesity (REDEFINE 1).N Engl J Med, 2025; DOI 10.1056/NEJMoa25020813,417 adults, 68 weeks, four arms.

In context

Cagrilintide is a once-weekly analogue of amylin, a hormone the pancreas releases alongside insulin that signals fullness. On its own it produced about 12% weight loss over 68 weeks; combined with semaglutide as CagriSema it produced 22.7% in a 3,417-person phase 3 trial published in the New England Journal of Medicine. Neither is approved yet, and the combination missed the 25% figure its developer had signalled.

Cagrilintide is investigational. Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is Cagrilintide proven to cause GI side effects?
Not yet settled. Phase 3 — LYO grades it B, meaning probable but liable to change as trials read out.
What studies are behind the grade?
Mostly mild-to-moderate nausea and vomiting, easing over time; the profile reported as consistent with GLP-1 drugs.
Is Cagrilintide approved for this?
No. Cagrilintide is investigational; it is not an approved medicine for any indication in the jurisdictions LYO covers.

Other outcomes for Cagrilintide

Reviewed 2 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →