What the studies show
Same design in 32 men: increased sexual-brain activation and a modest increase in penile tumescence to erotic stimuli. Single infusion; no data on repeated use.
A few small or poorly-controlled human studies. Enough to be interesting; not enough to count on. Most of what gets called “clinically proven” online lives here.
- 1Mills EG, et al. Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial.JAMA Netw Open, 2023; DOI 10.1001/jamanetworkopen.2022.5431332 men, double-blind crossover.
In context
Kisspeptin is the hormone that switches on the reproductive axis: it makes the hypothalamus release GnRH, which drives LH, FSH and the sex hormones. In people it reliably raises LH within minutes, has been used as an egg-maturation trigger in IVF in phase 2 trials, and in two small randomised crossover trials at Imperial College London (32 women, 32 men) increased sexual-brain activation and reduced sexual aversion in people with low sexual desire. All of that is research-scale. It is not an approved medicine anywhere and is prohibited for male athletes.
Kisspeptin is not approved. Legal status differs by country — see the regulation section or the jurisdiction pages.
Questions
Is Kisspeptin proven to help with sexual desire and arousal?
What studies are behind the grade?
Is Kisspeptin approved for this?
Other outcomes for Kisspeptin
- BLH and testosterone releaseMany small studies
- CIVF egg maturation trigger2 phase 2 trials
- CSexual desire (women with HSDD)1 crossover RCT (n=32)
- CSafetyadverseSmall studies
Reviewed 3 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →