Claimed effect · Ecnoglutide

Does Ecnoglutide help with blood glucosein type 2 diabetes?

B
Grade B — probable, not settled2 phase 3 RCTs (EECOH-1, EECOH-2) · effect size: large
Short answerProbable, not settled. Human data exist (2 phase 3 RCTs (EECOH-1, EECOH-2)) and mostly agree, showing a large effect — but too few, too small, or not yet peer-reviewed for a firm answer. A placebo-controlled monotherapy trial and a 52-week non-inferiority trial against dulaglutide, both published in 2025.

What the studies show

A placebo-controlled monotherapy trial and a 52-week non-inferiority trial against dulaglutide, both published in 2025.

Human trials exist and mostly agree, but there are too few of them, they are too small, or one big one is still reading out. Expect the grade to move.

  1. 1
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In context

Ecnoglutide is a once-weekly GLP-1 receptor agonist developed by Sciwind Biosciences in China, engineered to favour the cAMP signalling pathway. In a 664-person phase 3 trial published in 2025, Chinese adults with overweight or obesity lost 13.2% at 40 weeks on the top dose against 0.1% on placebo. Two phase 3 diabetes trials are also published. It is not approved in any region this site covers.

Ecnoglutide is investigational (phase 3 published). Legal status differs by country — see the regulation section or the jurisdiction pages.

Questions

Is Ecnoglutide proven to help with blood glucosein type 2 diabetes?
Not yet settled. 2 phase 3 RCTs (EECOH-1, EECOH-2) — LYO grades it B, meaning probable but liable to change as trials read out.
What studies are behind the grade?
A placebo-controlled monotherapy trial and a 52-week non-inferiority trial against dulaglutide, both published in 2025.
Is Ecnoglutide approved for this?
No. Ecnoglutide is investigational (phase 3 published); it is not an approved medicine for any indication in the jurisdictions LYO covers.

Other outcomes for Ecnoglutide

Written and maintained by LYO Research — how pages are written and checked. Reviewed 23 September 2026. Grades count human evidence only; see how LYO grades. Not medical advice. Correct this page →