{"id":"vilon","name":"Vilon","aliases":["Lys-Glu","lysyl-glutamic acid","thymic bioregulator dipeptide"],"url":"https://lyoresearch.com/compounds/vilon","class":{"id":"longevity-compounds","name":"Mitochondrial, antioxidant and longevity compounds","url":"https://lyoresearch.com/classes/longevity-compounds"},"summary":"Vilon is the dipeptide lysine–glutamate, one of the short synthetic peptides derived by Vladimir Khavinson's St Petersburg institute from thymic extracts and sold as an immune and anti-ageing 'bioregulator'. Its indexed evidence is mice — longer lifespan and fewer spontaneous tumours in the institute's own studies — and cultured cells. No human trial of any design exists. It is not approved anywhere this site covers.","overall_grade":"D","overall_grade_meaning":"no human evidence","human_trials":"0","regulatory_status":"Not approved","molecule":{"formula":"C11H21N3O5","molecular_weight":"275.30","cas":"45234-02-4","pubchem_cid":7010502,"note":"Recorded as lysylglutamic acid"},"pharmacokinetics":{"basis":"none","route":"Oral or injected as sold","half_life":"No human pharmacokinetic data","licensed_regimen":null,"product":null,"source":null},"outcomes":[{"outcome":"Any outcome in humans","grade":"D","grade_meaning":"no human evidence","effect_size":"not measurable","adverse":false,"human_studies":"0","evidence":"A PubMed search returns 57 results, none a human trial. The 'chromatin reactivation' work used lymphocytes from elderly donors in culture.","references":[{"citation":"PubMed search: vilon Lys-Glu dipeptide — 57 results, no human trial.","where":"PubMed, searched 2026-09-23","url":"https://pubmed.ncbi.nlm.nih.gov/?term=vilon+Lys-Glu+dipeptide"}]},{"outcome":"Lifespan and tumour incidence (mice)","grade":"D","grade_meaning":"no human evidence","effect_size":"moderate","adverse":false,"human_studies":"Animal only","evidence":"Female CBA mice given vilon from six months lived longer and developed fewer spontaneous tumours in the institute's studies; the same group reports opposite-direction effects in other models.","references":[{"citation":"Khavinson VK, et al. Effect of vilon on biological age and lifespan in mice.","where":"Bull Exp Biol Med, 2000","url":"https://pubmed.ncbi.nlm.nih.gov/11140587/"}]}],"regions":[{"region":"European Union","status":"Not authorised","note":"No marketing authorisation."},{"region":"United States","status":"Not approved","note":"Not FDA-approved."},{"region":"United Kingdom","status":"Not licensed","note":"Unlicensed."},{"region":"Australia","status":"Not on the ARTG","note":"Not registered."},{"region":"Canada","status":"Not authorised","note":"No Drug Identification Number."},{"region":"Sport (WADA)","status":"Prohibited at all times","note":"Unapproved, so S0 (non-approved substances)."}],"faq":[{"q":"Does vilon boost immunity?","a":"In mice and cell culture, effects are reported by its developers. No human trial has tested it."},{"q":"Is vilon the same as thymalin?","a":"No. Thymalin is an undefined calf-thymus extract; vilon is a defined dipeptide the same group derived from it. Neither has a randomised human trial."}],"references":[{"cite":"PubMed search: vilon Lys-Glu dipeptide — 57 results, no human trial.","where":"PubMed, searched 2026-09-23","url":"https://pubmed.ncbi.nlm.nih.gov/?term=vilon+Lys-Glu+dipeptide"},{"cite":"Khavinson VK, et al. Effect of vilon on biological age and lifespan in mice.","where":"Bull Exp Biol Med, 2000","url":"https://pubmed.ncbi.nlm.nih.gov/11140587/","note":"Mice."}],"last_reviewed":"2026-09-23","literature_searched_to":"2026-09-23","changelog":[{"date":"2026-09-23","note":"Initial publication. Grade D: no human study."}],"license":"CC BY 4.0 — cite as “LYO Research” with a link.","methodology":"https://lyoresearch.com/methodology"}