{"id":"selank","name":"Selank","aliases":["tuftsin analogue","TP-7"],"url":"https://lyoresearch.com/compounds/selank","class":{"id":"nootropic-peptides","name":"Nootropic and sleep peptides","url":"https://lyoresearch.com/classes/nootropic-peptides"},"summary":"Selank is a synthetic analogue of tuftsin, an immune-signalling peptide, developed in Russia alongside Semax and registered there as an anxiolytic. Small Russian studies report anxiety reduction comparable to benzodiazepines without sedation; none has been replicated internationally or published to standards that allow the claim to be checked. It is not approved in the EU, US or UK.","overall_grade":"D","overall_grade_meaning":"no human evidence","human_trials":"Russian-language, small","regulatory_status":"Not approved (outside Russia)","molecule":{"formula":"C33H57N11O9","molecular_weight":"751.9","cas":"129954-34-3","pubchem_cid":11765600,"note":null},"pharmacokinetics":{"basis":"none","route":"Intranasal as sold","half_life":"No human pharmacokinetic data","licensed_regimen":null,"product":null,"source":null},"outcomes":[{"outcome":"Anxiety","grade":"D","grade_meaning":"no human evidence","effect_size":"not measurable","adverse":false,"human_studies":"Small Russian studies","evidence":"Reports of anxiety reduction in generalised anxiety disorder, some comparing against benzodiazepines. Small, from the originating institutes, not independently replicated.","references":[{"citation":"Searches of PubMed and trial registries for Selank human trials outside Russia.","where":"LYO literature search, September 2026","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Selank+anxiety+randomized+trial"}]},{"outcome":"Cognitive effects","grade":"D","grade_meaning":"no human evidence","effect_size":"not measurable","adverse":false,"human_studies":"None controlled internationally","evidence":"Secondary claims from the same small studies.","references":[]},{"outcome":"Safety in humans","grade":"D","grade_meaning":"no human evidence","effect_size":"not measurable","adverse":true,"human_studies":"No systematic international data","evidence":"Reported as well tolerated in Russian use; no modern pharmacovigilance dataset.","references":[]}],"regions":[{"region":"European Union","status":"Unauthorised in the EU","note":"Authorised in Russia only. Supplying it for human use in the EU is an offence under national medicines law."},{"region":"United States","status":"Not approved","note":"Its 503A nomination is listed as withdrawn since April 2026 and it was not among the peptides reviewed in July 2026. Sold as an unapproved 'research chemical'."},{"region":"United Kingdom","status":"Unlicensed medicine","note":"No MHRA licence; supply for human use is an offence."},{"region":"Australia","status":"Schedule 4, unapproved","note":"Prescription-only substance not on the ARTG. Possession without a prescription is an offence; imports without a prescription are seized."},{"region":"Canada","status":"Not authorised","note":"No Drug Identification Number; selling it is illegal. Residents cannot import prescription drugs by mail."},{"region":"Sport (WADA)","status":"Not on the list","note":"Approved in Russia, so S0 does not apply, and it is not named."}],"faq":[{"q":"Is Selank as effective as benzodiazepines?","a":"Some small Russian studies make that comparison. None has been replicated internationally, and the reporting does not allow the claim to be checked. Treat it as untested rather than established."},{"q":"Is Selank addictive?","a":"It is claimed not to be, on the basis that it does not act directly on benzodiazepine receptors. No long-term human study has examined dependence."}],"references":[{"cite":"Searches of PubMed and trial registries for Selank human trials outside Russia.","where":"LYO literature search, September 2026","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Selank+anxiety+randomized+trial","note":"No independently replicated randomised trials identified."}],"last_reviewed":"2026-09-02","literature_searched_to":"2026-09-02","changelog":[{"date":"2026-09-02","note":"Initial publication. Graded D on absence of internationally reported controlled evidence."}],"license":"CC BY 4.0 — cite as “LYO Research” with a link.","methodology":"https://lyoresearch.com/methodology"}